IMPORTANCE OF AGGRAVATING FACTORS IN THE DEVELOPMENT OF DESTRUCTIVE PULMONARY TUBERCULOSIS

Background: At present, despite the generally favorable pathomorphosis of tuberculosis (TB), a number factors that have negative impact on epidemiological situation, clinical manifestations and treatment outcomes remain. Objective: To determine role aggravating in development destructive pulmonary tuberculosis. Material methods: A prospective cohort study was conducted. The patients who were admitted to inpatient department Grodno Regional Clinical Center "Phthisiology", as well Republican Tuberculosis Hospital "Novoelnya" examined. Depending prevailing factor, divided into 10 groups. In addition, 2 more groups with presence extensive drug resistance mycobacterium (XDR MBT) formed. obtained results indicate significant influence formation processes lungs. As cases terms these should be considered TB, accompanied by diabetes mellitus (DM), alcohol dependence syndrome (ADS), chronic nonspecific respiratory diseases (HNRD), those arrived from correctional labor institutions several at same time. Results: analysis shows all cohorts patients, frequency decay cavities exceeds without risk factors. Conclusions: forms MDR-TB depends most them this regard are DM, time, ADS, staying HNRD. Factors such contact or gastrointestinal tract do not effect destruction lungs MDR-TB. XDR-TB, highest (over 70%) is observed, it reaching 76.0% XDR-TB combined ADS.